Jember Medical Journal

Mesenchymal Stem Cell Therapy to Reduce the Neurological Deficit of Chronic Ischemic Stroke Patients: A Systematic Review

surya nita — 2024-11-12

Current ischemic and hemorrhagic stroke treatments are limited by a narrow golden period and lack of regenerative benefits, so stem cell therapy emerges as an ideal candidate for functional recovery in stroke patients. Stem cell therapy, still being studied, is expected to repair ischemic areas damaged by stroke to restore their physiological functions and reduce
neurological deficits in chronic stroke patients. This study aimed to determine the therapeutic efficacy of MSCs in reducing neurological deficits in chronic ischemic stroke patients. We conducted a systematic review. We searched PubMed, Cochrane Library, Science Direct, and Springer Link from inception until December 2022 for cohort studies dealing with mesenchymal stem cell therapy for patients with ischemic stroke. The citation-searching method in this study collected 1,038 articles using the advanced searching method and 8 articles using the citation-searching method, bringing the total number of articles to 1,046. The exclusion criteria used were articles with systematic reviews and meta-analyses and articles that were not accessible in full text. Based on the results of a systematic review study conducted, the conclusion that can be drawn is that MSCs therapy has proven effective in reducing neurological deficits in chronic ischemic stroke patients in terms of the decreased NIHSS score.

Perbandingan Regulasi dan Kondisi Faktual Penggunaan Pestisida di Asia Tenggara

Muhammad Afiful Jauhani — 2024-11-12

Indonesia merupakan negara agraris dengan 40,6 juta penduduknya bekerja pada sektor pertanian. Akan tetapi, saat ini pemerintah Indonesia masih mengimpor produk pertanian dari negara lain, khususnya di Asia Tenggara, untuk memenuhi kebutuhan konsumsi dalam negeri. Kegiatan pertanian di berbagai negara umumnya menggunakan pestisida sebagai pengendali hama sehingga produk pertanian sangat mungkin terpapar pestisida yang menyebabkan gangguan kesehatan. Dalam rangka pengendalian dampak gangguan kesehatan akibat pestisida, diperlukan kebijakan pemerintah. Namun, kebijakan yang ada saat ini belum sepenuhnya dilaksanakan sehingga perlu diketahui kondisi faktual mengenai penggunaan pestisida. Penelitian ini bertujuan untuk menganalisis peraturan dan kondisi faktual mengenai penggunaan pestisida pada negara-negara di Asia Tenggara. Metode penelitian menggunakan tinjauan literatur menggunakan PICO dan
kriteria inklusi yang telah ditentukan. Hasil penelitian menunjukkan bahwa negara-negara di Asia Tenggara telah memiliki regulasi yang mengatur tentang pestisida, meskipun masih terdapat beberapa negara yang belum mengatur perihal pestisida secara menyeluruh, Misalnya Singapura belum mencntumkan aspek pengujian, pembuatan, iklan, dan pemusnahan; Brunei Darussalam belum mencantumkan aspek pengujian, iklam, dan pencabutan izin.. Faktanya, masih banyak permasalahan terkait kepatuhan dan penerapan aturan mengenai penggunaan pestisida yang berdampak pada keamanan pangan pada negara-negara di Asia Tenggara. Peran pemerintah untuk mengendalikan dampak negatif yang diakibatkan pestisida masih perlu untuk dioptimalkan, melalui monitoring dan evaluasi ketat terhadap penggunaan pestisida dan pengawasan terhadap keamanan produk pangan hasil pertanian.

A Stillborn Baby with Tetra-amelia Syndrome in Jember: A Case Report

Daniel Alexander Suseno — 2024-11-12

Tetra-amelia syndrome is a rare congenital disorder characterized by the absence of all four extremities. This extremity disorder occurs in 1 in 1,300 to 2,000 births. This condition is caused by genetic mutations in the WNT3 and RSPO2 genes. Specific risk factors for tetra-amelia syndrome remain unclear. This is also due to the lack of studies that discuss specific risk factors for tetra-amelia syndrome. In this case report, we discuss a stillborn baby with tetra-amelia syndrome to a mother with various pregnancy risk factors in Jember. This case report aims to examine the presence of several risk factors in the mother and their relationship with congenital disorders, especially tetra-amelia syndrome.

Anesthetic Management of Laparoscopic Surgery on a Pediatric Patient: Case Report

Adelia Handoko — 2024-11-12

Inguinal hernia is an opening on myofascial oblique muscle and transversal muscle or the failure of Nuck canal or processus vaginalis during the gestation week which allows herniation of intra-abdominal or extraperitoneal organ. A 5-year-old child was diagnosed with a left lateral inguinal hernia. The results of the inguinal ultrasound showed movement and movement of the intestines in the left inguinal area through a defect measuring approximately 2.96 centimeters. The patient was planned to undergo laparoscopic high ligation hernia. Laparoscopic technique in adult commonly applied with special consideration. However, the practice in pediatric patient could be more challenging for anesthesiologist. Although laparoscopic surgery is less invasive it could cause more stress due to the pressure of the intra-abdominal pneumoperitoneum by CO2 that is done during the procedure, which then causes hypercapnea due to the absorption of CO2, the decrease of tidal volume, and the decrease of end-tidal volume. Considering pediatric’s different physiology compared to adult and the risks of laparoscopic surgery, special anesthesia management should be conducted.