Journal of Agropharmacy

Formulasi Dan Evaluasi Sifat Fisik Pasta Ekstrak Binahong (Anredera cordifolia (Ten) Steenis) Dan Cangkang Telur Ayam Dengan CMC Na Sebagai Pengikat

Mikhania Christiningtyas Eryani, Agnis Pondineka Ria Aditama — Sun, 28 Jul 2024 00:00:00 +0700

Binahong (Anredera cordifolia (Ten) Steenis) is a natural ingredient that can prevent tooth decay due to plaque. The purpose of this study was to formulate and evaluate the physical properties of binahong extract paste and chicken egg shells with various concentrations of CMC Na as a binder. The paste was formulated with various concentrations of CMC Na, namely 1.5% (F1), 2% (F2) and 2.5% (F3). The physical properties of the paste studied included organoleptic, homogeneity, pH, viscosity, spreadability and foam height. The results showed that variations in the concentration of CMC Na affected the organoleptic physical properties of color, viscosity and foam height of the paste. However, variations in the concentration of CMC Na had no effect on the pH and spreadability of the paste.

Optimasi Gliserin dan Propilen Glikol dalam Sediaan Antioksidan Essence Ekstrak Kayu Secang (Caesalpinia sappan L.)

Lidya Ameliana, Lina Winarti, Talidah Alqibtiyah Roja — Sun, 28 Jul 2024 00:00:00 +0700

Facial skin problems are often caused by skin frequently exposed to free radicals, causing damage to skin cells. Usually, skin damage is characterized by a non-smooth skin structure, the appearance of dark spots, wrinkled skin, and dull skin. Antioxidants are one of the compounds that can protect cells from the influence of free radicals and slow down or prevent the oxidation process. To help reduce, stop, and slow down the adverse effects of free radical exposure, antioxidant essence preparations are used. In this study, glycerin and propylene glycol have been optimized in the preparation of sappan wood extract essence as an antioxidant. The purpose of this study is to determine the optimum concentration of glycerin and propylene glycol as a humectant in the essence preparation of sappan wood extract. In this study, the evaluation carried out includes pH tests, viscosity, and IC 50 antioxidant activity. In this study, essence characterization tests were also carried out including organoleptics, homogeneity, and dispersibility. From the results of the pH test, it was found that all essence formulas had a pH in the range of 5.5-6.0; viscosity in the range of 1.0-2.0 dPa.s; and IC50 test of antioxidant activity in the range of 100-125 μg/mL. The optimum essence formula has a propylene glycol concentration of 10% with a desirability of 0.871, with a predicted pH value of 5.658, a viscosity value of 1.256 dPa.s, and an IC50 value of 106.473 (μg/mL).

Model Zebrafish (Danio rerio) Pada Uji Farmakologi dan Toksikologi

Niken Indriyanti, Sestia Wulandari, Vita Olivia Siregar — Sun, 28 Jul 2024 00:00:00 +0700

Drug development testing methods continues to result in representative data. The use of rodent experimental animals can still be replaced by using smaller experimental animals, namely zebrafish (Danio rerio). Pharmacological activity test can use zebrafish models that are induced a pathophysiology condition similar to leukemia, melanoma, pancreatic cancer, myocardial infarction, atherosclerosis, diabetes, obesity, Parkinson's disease, Alzheimer's disease, anxiety, muscular dystrophy, osteoporosis, psoriasis, wound, and inflammation. Toxicity tests using zebrafish include acute and chronic toxicity tests, toxicity tests on the heart and liver, and neurotoxic effects. Zebrafish is an ideal model for measuring disease-specific biomarkers and toxicity biomarkers in humans.

Evaluasi Penggunaan Antibiotik pada Pasien ISPA Non-pneumonia di Puskesmas Senduro Kabupaten Lumajang Tahun 2019

Sun, 28 Jul 2024 00:00:00 +0700

Acute Respiratory Infection (ARI) is an infectious disease of the upper and lower respiratory tract. Non-pneumonic ARI is mostly caused by viral infections so symptomatic therapy can be given, but it can also be caused by bacterial infections so antibiotic therapy is needed. Unwise use of antibiotics can increase bacterial resistance, thereby increasing morbidity and mortality rates. Regular evaluations need to be carried out to reduce the unwise use of antibiotics. The evaluation method that can be used is a quantitative method (ATC/DDD) to determine trends in antibiotic use. This research was conducted on 278 outpatient non-pneumonic ARI patients at the Senduro Lumajang Community Health Center in 2019, with the aim of knowing patient characteristics, antibiotic use profile, and description of antibiotic use using the ATC/DDD method. The results showed that female patients (n=154; 55.4%), were more dominant than male (n=124; 44.6%), patients with the highest age range being 36-45 years (n=70; 25, 2%), the highest diagnosis of ARI was other acute infections of the upper respiratory tract (J06) (n=147; 52.9%), the most commonly used antibiotic was amoxicillin (n=227; 81.6%) and the most rarely used was cefadroxil (n=13; 4.7%). Based on the evaluation results using the ATC/DDD method, it shows that amoxicillin is the antibiotic with the highest DDD value of 7.5 DDD/1000 patients/day and the antibiotic levofloxacin with the lowest DDD value of 0.3 DDD/1000 patients/day.

Baricitinib for the treatment of COVID-19

Firdha Aprillia Wardhani, Devina, Yunita Dyah Kusumaningrum, Adelia Firandi — Sun, 28 Jul 2024 00:00:00 +0700

Baricitinib which is one of the therapies for rheumatoid arthritis is a JAK inhibitor. WHO recommended therapy with the combination of baricitinib and corticosteroids in COVID-19 patients with severe or critical condition. Effectivity and safety assessment of Baricitinib use were carried out by reviewing the literature published between December 2019 – February 2022, and showed that the use of Baricitinib in COVID-19 patients resulted in an improvement of lung function, improvement of oxygen saturation, higher recovery rate, and lower mortality, with similar adverse event incidence. A loading dose or a higher dose can be recommended for patient with caution and consideration of higher possibility in the incidence of adverse events

Daftar Isi

Sun, 13 Oct 2024 00:00:00 +0700